Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Farnesol, a Morphogenetic Autoregulatory Substance in the Dimorphic Fungus Candida albicans, Inhibits Hyphae Growth through Suppression of a Mitogen-Activated Protein Kinase Cascade
Tatsuki SatoToshihiko WatanabeTakeshi MikamiTatsuji Matsumoto
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2004 Volume 27 Issue 5 Pages 751-752

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Abstract

Candida albicans grew in hyphal form in RPMI1640, however, addition of farnesol inhibited the formation. Farnesol did not affect the expression of mRNAs related to cAMP-EFG1 pathways. The mRNAs (HST7 and CPH1) in mitogen activated protein kinase (MAP) cascades were decreased in farnesol-treated cells, but CST20 was not. Furthermore, expression of general amino acid permease 1 (GAP1) was decreased by farnesol. We concluded that farnesol inhibits a MAP kinase cascades, and the suppression is a cause of interruption of hyphae formation.

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© 2004 The Pharmaceutical Society of Japan
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