Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Tissue Distribution after Intravenous Dosing of Micafungin, an Antifungal Drug, to Rats
Toshiro NiwaYoshiko YokotaAkira TokunagaYasuhiro YamatoAkira KagayamaTomoichi FujiwaraJunko HatakeyamaMasaharu AnezakiYuko OhtsukaAkira Takagi
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2004 Volume 27 Issue 7 Pages 1154-1156

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Abstract

The tissue distribution after an intravenous dose of micafungin (1 mg/kg), a new echinocandin-like lipopeptide antifungal agent, to male rats was investigated. Micafungin in plasma disappeared biexponentially with a terminal half-life of 5.03 h. Micafungin concentrations in liver, kidney, and lung at the first sampling time (5 min) after dosing were 1.15, 1.64, and 2.58-fold higher than the plasma concentration, and the AUC0—∞ were 1.61, 3.42, and 2.89-fold higher than that for plasma. The terminal half-lives for these tissues were 5.14, 4.87, and 5.31 h, respectively, which were comparable to those for plasma. These results suggest that micafungin distributes rapidly and moderately into tissues such as the liver, kidney, and lungs, and that the concentrations in tissues decreased in parallel with the unchanged drug in plasma.

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© 2004 The Pharmaceutical Society of Japan
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