Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Biotransformation of Sinesetin by the Larvae of the Common Cutworm (Spodoptera litura)
Yoshiharu OkunoMitsuo Miyazawa
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2004 年 27 巻 8 号 p. 1289-1292

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Biotransformation of sinesetin (1) by larvae of Spodoptera litura was investigated. Compound 1 was converted to a new flavonoid, (+)-5,7,3′,4′-tetramethoxyflavone-6-O-β-D-glucoside (4), and two known flavones, 4′-hydroxy-5,6,7,3′-tetramethoxyflavone (2) and 6-hydroxy-5,7,3′,4′-tetramethoxyflavone (3). These structures were established by IR, HR-EI-MS, HR-FAB-MS, 1D NMR, and 2D NMR spectral studies. The results indicate that the metabolic reaction of compound 1 by larvae of S. litura proceeded along two pathways; the main pathway is demethylation at the C-6 position followed by glucosylation, and the minor pathway is demethylation at the C-4′ position.

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© 2004 The Pharmaceutical Society of Japan
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