Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Effects of Trifluoromethyl Ketones on the Motility of Proteus vulgaris
Krisztina WolfartAnnamaria MolnarMasami KawaseNoboru MotohashiJoseph Molnar
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2004 Volume 27 Issue 9 Pages 1462-1464

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Abstract

In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1—8) in Proteus vulgaris (P. vulgaris) cultures. Among them, 1-(2-benzoxazoyl)-3,3,3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MIC. Our results suggest the possibility of an inhibitory action of TF compounds on the proton motive forces by affecting the action of biological motor and proton efflux in the membranes, resulting in a reduction of the ratio of running and the increased number of tumbling and non-motile cells.

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© 2004 The Pharmaceutical Society of Japan
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