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Biological and Pharmaceutical Bulletin
Vol. 28 (2005) No. 3 P 523-526




Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. These activities are comparable to those of cimetidine.

Copyright © 2005 The Pharmaceutical Society of Japan

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