Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia
Hyeon Gyeong YooJin Sook KimSe Rah LeeHyun Keol PyoHyung In MoonJong Hee LeeOh Sang KwonJin Ho ChungKyu Han KimHee Chul EunKwang Hyun Cho
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2006 年 29 巻 6 号 p. 1246-1250

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Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10−9—10−7 M) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10−8 M) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-β1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-β1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-β1 antibody (10 μg/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-β1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-β1 expression may explain another possible mechanism how finasteride works in AGA.

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© 2006 The Pharmaceutical Society of Japan
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