Biological and Pharmaceutical Bulletin
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Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from Kaempferia pandurata ROXB.
Ji-Hoon YoonJae-Seok ShimYumi ChoNam-In BaekChan-Woo LeeHan-Sung KimJae-Kwan Hwang
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2007 Volume 30 Issue 11 Pages 2141-2145

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Abstract

This study was carried out to investigate the in vitro effects of isopanduratin A and 4-hydroxypanduratin A isolated from Kaempferia pandurata ROXB. on melanin biosynthesis and tyrosinase activity. Two chalcone compounds, isopanduratin A and 4-hydroxypanduratin A, were isolated from the ethyl acetate fraction of ethanol extract as the active principles. Compared with phenylthiourea (IC50=34.3 μM) as a positive control, the depigmentation IC50 values for isopanduratin A and 4-hydroxypanduratin A were 10.6 μM and 23.2 μM, respectively. The compounds also significantly inhibited the activity of tyrosinase, the enzyme that converts DOPA (3,4-dihydroxyphenylalanine) to dopachrome in the biosynthetic process of melanin. The IC50 values of isopanduratin A and 4-hydroxypanduratin A for tyrosinase were 10.5 μM and >30 μM, respectively, while that of phenylthiourea was 47.6 μM. The tyrosinase protein level was also significantly decreased by isopanduratin A and 4-hydroxypanduratin A. The results indicate that isopanduratin A and 4-hydroxypanduratin A isolated from K. pandurata ROXB. are promising compounds that could be useful for treating hyperpigmentation as skin-whitening agents.

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© 2007 The Pharmaceutical Society of Japan
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