Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Screening for Microbial Metabolites Affecting Phenotype of Caenorhabditis elegans
Daisuke YamamuroRyuji UchidaYoko TakahashiRokuro MasumaHiroshi Tomoda
著者情報
ジャーナル フリー

2011 年 34 巻 10 号 p. 1619-1623

詳細
抄録

Microbial samples, including our library of known microbial compounds (ca. 300) and microbial culture broths (ca. 9000), were screened for small molecules affecting the phenotype of Caenorhabditis elegans. As a result, seven known compounds were found to induce phenotypic abnormality of C. elegans. Staurosporine exhibited morphological defects in the vulva and tail of C. elegans, avermectin B1a exhibited hatching inhibition of starting eggs on day 1 at 25—100 μM and growth inhibition at 0.01—12.5 μM, siccanin and antimycin A inhibited the growth of C. elegans, and fluorouracil inhibited hatching of eggs newly spawned by adult C. elegans. Toromycin induced morphological defects in the intestine. 5-(4-Methoxyphenyl)-oxazole, isolated as a fungal metabolite for the first time, inhibited the hatching of eggs newly spawned by adult C. elegans.

著者関連情報
© 2011 The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top