Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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News from the End of the Gut—How the Highly Segmental Pattern of Colonic HCO3 Transport Relates to Absorptive Function and Mucosal Integrity
Oliver BachmannUrsula Seidler
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2011 年 34 巻 6 号 p. 794-802

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A number of transport mechanisms in the colonic epithelium contribute to HCO3 movement across the apical and basolateral membranes, but this ion has been largely regarded as a by-product of the transport functions it is involved in, such as NaCl- or short chain fatty acid (SCFA) absorption. However, emerging data points to several specific roles of HCO3 for colonic epithelial physiology, including pH control in the colonic surface microenvironment, which is important for transport- and immune functions, as well as the secretion and the rheological properties of the mucus gel. Furthermore, recent studies have demonstrated that colonic HCO3 transporters are expressed in a highly segmental as well as species-specific manner. This review summarizes recently gathered information on the functional anatomy of the colon, the roles of HCO3 in the colonic epithelium, colonic mucosal integrity, and the expression and function of HCO3 transporting mechanisms in health and disease.

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© 2011 The Pharmaceutical Society of Japan
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