Biological and Pharmaceutical Bulletin
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Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Batatasin I, a Naturally Occurring Phenanthrene Derivative, Isolated from Tuberous Roots of Dioscorea batatas Suppresses Eicosanoids Generation and Degranulation in Bone Marrow Derived-Mast Cells
Yue LuMeihua JinSang-Jo ParkKun Ho SonJong-Keun SonHyeun Wook Chang
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2011 年 34 巻 7 号 p. 1021-1025

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To find anti-inflammatory compounds from the tuberous roots of Dioscorea batatas, we isolated 6-hydroxy-2,4,7-trimethoxyphenanthrene (batatasin I) from the dichloromethane (CH2Cl2) fraction of this plant. Batatasin I inhibited both the generation of prostaglandin D2 (PGD2), leukotriene C4 (LTC4) and degranulation reaction in mouse bone marrow-derived mast cells (BMMCs). This compound inhibited cyclooxygenase-2 (COX-2) dependent PGD2 generation in a dose dependent manner, with IC50 values of 1.78 μM. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in the quantity of the PGD2 generation was accompanied by a decrease in the COX-2 protein level. In addition, this compound also inhibited the production of 5-lipoxygenase (5-LOX) dependent LTC4 in a dose dependent manner (IC50, 1.56 μM). Batatasin I also inhibited the mast cell degranulation reaction (IC50, 6.7 μM) in BMMCs. This result indicates that batatasin I could be developed as an anti-inflammatory agent through further investigation.

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© 2011 The Pharmaceutical Society of Japan
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