Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Anti-proliferative Neolignans from Saururus chinensis against Human Cancer Cell Lines
You Jin LeeJinhee KimJin-Mu YiSe-Mi OhNo Soo KimHaejin KimDal-Seok OhOk-Sun BangJun Lee
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2012 Volume 35 Issue 8 Pages 1361-1366

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Abstract

Activity-guided fractionation of an 80% EtOH extract from the aerial parts of Saururus chinensis led to isolation of three anti-proliferative neolignans (13) along with four flavonoids (47) and four aristolactams (811). Their chemical structures were identified by analysis of spectroscopic data. All compounds 111 were evaluated for their activities against 28 human cancer cell lines using an in vitro cell proliferation assay. Compounds 13 showed potent anti-proliferative activities against cervical (C33a, IC50=0.01 µM for 1; 0.28 µM for 2; 2.80 µM for 3) and lung (NCI-H460, IC50=0.05 µM for 1; 1.37 µM for 2; 6.46 µM for 3) cancer cells without any remarkable cytotoxic effects on human normal lung cells as a control. Taken together, these data demonstrated the identification of anti-proliferative neolignans which are active components of S. chinensis.

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© 2012 The Pharmaceutical Society of Japan
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