Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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The Essential Structures of ISP-I that Influence Serine Palmitoyltransferase Inhibition in Chinese Hamster Ovary Cells
Koji MizukoshiKatsuo MatsumotoRyoji HiroseTetsuro Fujita
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2012 Volume 35 Issue 8 Pages 1349-1353

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Abstract

We investigated the structure–activity relationship between various ISP-I (myriocin, thermozymocidin) analogous which has sphingosine-like structure and serine palmitoyltransferase (SPT) in Chinese hamster ovary (CHO) cells utilizing sphingolipid production as a marker. Our data suggest that the double bond and/or ketone group within the alkyl chain as well as the alkyl chain are necessary for ISP-I to inhibit SPT. In addition, a serine structure is necessary for SPT inhibitory activity, which confirms previous findings.

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© 2012 The Pharmaceutical Society of Japan
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