Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
The Role of Interleukin-19 in Contact Hypersensitivity
Yasuyuki FujimotoTakashi FujitaNobuyuki KuramotoMitsuru KuwamuraTakeshi IzawaKazuhiro NishiyamaNatsuho YoshidaHidemitsu NakajimaTadayoshi TakeuchiYasu-Taka Azuma
Author information
JOURNAL FREE ACCESS FULL-TEXT HTML

2018 Volume 41 Issue 2 Pages 182-189

Details
Abstract

Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells. There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. Contact hypersensitivity (CHS) is T cell-mediated cutaneous inflammation. Therefore, we asked whether IL-19 causes CHS. We investigated the immunological role of IL-19 in CHS induced by 1-fluoro-2,4-dinitrofluorobenzene as a hapten. IL-19 was highly expressed in skin exposed to the hapten, and ear swelling was increased in IL-19 knockout mice. The exacerbation of the CHS response in IL-19 knockout mice correlated with increased levels of IL-17 and IL-6, but no alterations were noted in the production of interferon (IFN)γ and IL-4 in the T cells of the lymph nodes. In addition to the effect on T cell response, IL-19 knockout mice increased production of inflammatory cytokines. These results show that IL-19 suppressed hapten-dependent skin inflammation in the elicitation phase of CHS.

Graphical Abstract Fullsize Image
Content from these authors
© 2018 The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top