Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Development of an Inexpensive and Rapid Operation Device for High-Throughput Real-Time Quantitative PCR-Based CYP2D6 CNV Genotyping
Miho ImaiMadoka KisoiMiwako MoritsuguShigenori MurataAtsushi IchikawaKenji Kinoshita
著者情報
ジャーナル フリー HTML

2019 年 42 巻 10 号 p. 1761-1765

詳細
抄録

The CYP2D6 gene is the most well characterized gene involved in drug metabolism and is known to have both gene duplication and deletion variants. We report an optimized method for the determination of copy number variation (CNV) in the CYP2D6 gene by a novel purification process for a real-time quantitative PCR. This high-throughput low-cost method accurately determines CNV in the CYP2D6 gene enabling reliable estimates of disease prediction in large epidemiological samples.

Fullsize Image
著者関連情報
© 2019 The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top