Seasonal Variation in Diuretic-Induced Dehydration Using Spontaneous Reports of Adverse Events

Satoshi Nakao; Mika Maezawa; Kohei Shiota; Fumiya Goto; Koumi Miyasaka; Sakiko Hirofuji; Kiyoka Matsumoto; Moe Yamashita; Nanaka Ichihara; Yuka Nokura; Kana Sugishita; Tomofumi Yamazaki; Hideyuki Tanaka; Hirofumi Tamaki; Kazuhiro Iguchi; Mitsuhiro Nakamura

doi:10.1248/bpb.b25-00007

Regular Article

Seasonal Variation in Diuretic-Induced Dehydration Using Spontaneous Reports of Adverse Events

Satoshi Nakao, Mika Maezawa, Kohei Shiota, Fumiya Goto, Koumi Miyasaka, Sakiko Hirofuji, Kiyoka Matsumoto, Moe Yamashita, Nanaka Ichihara, Yuka Nokura, Kana Sugishita, Tomofumi Yamazaki, Hideyuki Tanaka, Hirofumi Tamaki, Kazuhiro Iguchi, Mitsuhiro Nakamura

Author information

Satoshi Nakao
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Department of Pharmacy, Kyushu University Hospital, 3–1–1 Maidashi, Higashi-ku, Fukuoka 812–8582, Japan
Mika Maezawa
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Kohei Shiota
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Fumiya Goto
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Koumi Miyasaka
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Sakiko Hirofuji
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Kiyoka Matsumoto
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Moe Yamashita
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Nanaka Ichihara
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Yuka Nokura
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Kana Sugishita
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Tomofumi Yamazaki
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Hideyuki Tanaka
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Hirofumi Tamaki
Laboratory of Community Pharmacy, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Kazuhiro Iguchi
Laboratory of Community Pharmacy, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan
Mitsuhiro Nakamura Corresponding author
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu 501–1196, Japan

Keywords: diuretic, dehydration, seasonal variation, adverse event, Japanese Adverse Drug Event Report database

JOURNAL OPEN ACCESS FULL-TEXT HTML
Supplementary material

2025 Volume 48 Issue 9 Pages 1335-1342

DOI https://doi.org/10.1248/bpb.b25-00007

Details

Abstract

Diuretics have long been central to the treatment of heart failure (HF) and hypertension, and are widely used in clinical settings. Herein, we performed a retrospective analysis of seasonal variations in diuretic-induced dehydration (DID) using the Japanese Adverse Drug Event Report (JADER) database, a platform that presents data on real-world clinical practice. A total of 11 diuretics prescribed in Japan, categorized into six groups, were included. The monthly reporting ratio (RR) of DID in the JADER database was determined from January 2003 to December 2023. DID was most common in January, followed by August. Furthermore, it was frequently reported during the winter months of December, January, and February. It is important for healthcare providers to understand that DID is common in both winter and summer, and thus recommend adequate water intake even in the former for patients taking diuretics. These findings can contribute to the management of dehydration in patients taking diuretics and are beneficial to healthcare professionals involved in the treatment of HF and hypertension.

Fullsize Image

Corresponding author

Register with J-STAGE for free!