Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
KINETICS OF p-AMINOHIPPURATE RENAL EXCRETION IN RABBITS
TAMOTSU KOIZUMI, MICHIHIRO UEDA, SEIICHI TAKADA, KAYOKO TADA
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Keywords: PAH disposition
JOURNALS FREE ACCESS

Volume 1 (1978) Issue 1 Pages 39-48

DOI https://doi.org/10.1248/bpb1978.1.39
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Abstract

The pharmacokinetics of p-aminohippurate (PAH) was investigated in rabbits by administering the compound intravenously as a bolus or as constant infusion. PAH was measured in plasma and in urine. Appropriate models are formulated, with the overall model describing PAH disposition consisting of 5 compartments.

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