Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES. X. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SEVERAL PURIN-6-YL BENZYL DISULFIDES AND THEIR RIBONUCLEOSIDES
MINEO SANEYOSHIMOTOKO INOMATATERUAKI SEKINEAKIO HOSHIFUMIKO FUKUOKA
著者情報
キーワード: Nakahara-Fukuoka sarcoma
ジャーナル フリー

1978 年 1 巻 3 号 p. 168-174

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抄録

Reaction of S-benzylthioisothiouronium hydrochloride with 6-mercaptopurine (1), 9-β-D-ribofuranosyl-6-mercaptopurine (2), 6-thioguanine (3) and 9-β-D-ribofuranosyl-6-thioguanine (4) afforded corresponding benzyl disulfide derivatives (5-8) in good yield. These compounds were converted easily to parent mercapto derivatives when they were treated with various reducing agents such as β-mercaptoethanol. Antitumor activity of compound 5 was higher than that of 1 both in ascites Sarcoma 180 and in Nakahara-Fukuoka sarcoma systems. However, toxicity and immunosuppressive activity of compound 5 and 6 were higher than those of 1 and 2, respectively.

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© The Pharmaceutical Society of Japan
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