Abstract
The effects of acetylcholine on pulse rate were examined in the conscious state of diabetic KK-CAy male mice. By subcutaneously-administered acetylcholine at 3 and 10 mg/kg the pulse rate was increased in the prediabetic state, whereas it was decreased in the diabetic state. The acetylcholine induced responses in pulse rate were significantly and multiply correlated with both the blood glucose level and the dose of acetylcholine in KK-CAy mice (r=0.47, p<0.01). The diabetic state and adrenalectomy produced an acetylcholine-hypersensitive syndrome, respectively. The hypersensitivity to acetylcholine in a whole body of diabetic mice was attenuated by repeated cold stress producing acetylcholine-subsensitivity, and was enhanced by adrenalectomy. The diabetic KK-CAy mice are an acetylcholine-hypersensitive animal model.
