CORRELATION BETWEEN ANTI-INFLAMMATORY ACTIVITY AND PERIPHERAL DRUG IN RAT AFTER ADMINISTRATION OF BIPHENYLYLACETIC ACID DERIVATIVES

Abstract

The relationship between the anti-inflammatory action and drug behaviors in vivo was investigated by administering five biphenylylacetic acid derivatives to rats. 1) With five drugs, an excellent linear relationship was recognized between % inhibition of carrageenin-induced edema and logarithm of drug concentration in peripheral compartment calculated pharmacokinetically (γ=0.76-0.96). 2) A good linear relationship between areas under % inhibition versus time curves, and logarithm of drug concentration in peripheral compartment versus time curves of each drug was also recognized (γ=0.86). These results suggested that intrinsic drug activities of each drug are approximately the same and drug effect may be restricted to their transporting abilities into peripheral compartment.