Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
DIRECT DETERMINATION OF OPIUM ALKALOID-BOVINE SERUM ALBUMIN CONJUGATE BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY
Yukihiro SHOYAMATomohiro FUKADATakashi TANAKAAkihiko KUSAIKazutetsu NOJIMA
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1993 Volume 16 Issue 10 Pages 1051-1053

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Abstract

Opium alkaloids (thebaine, codeine and morphine) have been conjugated with bovine serum albumin (BSA) to give individual antigen conjugates which are analyzed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. It became clear that 9 molecules of thebaine were contained in a thebaine-BSA conjugate. Codeine and morphine contents in individual conjugates were determined to be 12 and 6 molecules, respectively.

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© The Pharmaceutical Society of Japan
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