Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
A Novel Metabolite of 3, 4-Methylenedioxyamphetamine (MDA) : Formation of 3-Methyl-6, 7-methylenedioxy-1, 2, 3, 4-tetrahydroisoquinoline and Its Pharmacological Effect
中川 秀彦牧野 由紀子吉田 幸弘太田 茂広部 雅昭
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1993 年 16 巻 6 号 p. 579-582

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In 3, 4-methylenedioxyamphetamine (MDA)-treated rat brain and urine, 3-methyl-6, 7-methylenedioxy-1, 2, 3, 4-tetrahydroisoquinoline (3Me6, 7MDTIQ) was detected as a new metabolite. The content of 3Me6, 7MDTIQ in (R)-MDA-treated rat was significantly higher than that in (S)-MDA-treated brain and urine. This result suggests that this metabolism of MDA contains stereoselective pathways.The pharmacological effects of 3Me6, 7MDTIQ on behavior differed from those of MDA. The ambulation score of 3Me6, 7MDTIQ was significantly decreased compared to the control, and the rearing score of 3Me6, 7MDTIQ was moderately decreased compared to the control in an open-field test.

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