Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
A Glucan with Immunological Activities from the Tuber of Alisma orientale
Noriko SHIMIZUSadanori OHTSUMasashi TOMODARyoko GONDANaoko OHARA
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1994 Volume 17 Issue 12 Pages 1666-1668

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Abstract

A glucan, called alisman SI, was isolated from the tuber of Alisma orientale JUZEPCZ. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was 1.1×104. It is composed solely of D-glucose. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it has a high-branched glucan type structure mainly composed of α-1, 4-linked D-glucopyranosyl residues with partially α-1, 6-linked units and both 3, 4- and 4, 6-branching points. The polysaccharide exhibited significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as a pronounced anti-complementary activity.

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© The Pharmaceutical Society of Japan
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