Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibition of Carbon Tetrachloride-Induced Hepatotoxicity by Neopterins
Takeshi ICHOShuji KOJIMAKazumori YOSHIKAWATomoaki YOSHIMURAMasayuki SHIROTAYoshio KAJIWARAKatsuaki KITABATAKEKazuhiko KUBOTA
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1994 Volume 17 Issue 7 Pages 914-916

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Abstract

We investigated the inhibitory effects of neopterin (NP) and its reduced form, 5, 6, 7, 8-tetrahydroneopterin (NPH4), on carbon tetrachloride (CCl4)-induced hepatotoxicity. In in vivo experiments, intraperitoneal administration of NP or NPH4 significantly inhibited the elevation of plasma alanine aminotransferase activity induced by CCl4 in mice. In in vitro experiments using cultured rat hepatocytes, CCl4 induced in a manner which was both time- and dose-dependent lactate dehydrogenase release, and the addition of NP or NPH4 to the culture-medium significantly inhibited its release from cells. NPH4, but not NP, reacted directly with a stable radical, 1, 1-diphenyl-2-picrylhydrazyl. These results suggest that NP and NPH4 inhibit CCl4-induced hepatotoxicity through different mechanisms.

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