Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Characterization of a Novel Heteroglucan from the Rhizome of Cnidium officinale Exhibiting High Reticuloendothelial System-Potentiating and Anti-complementary Activities
Masashi TOMODANaoko OHARANoriko SHIMIZURyoko GONDA
Author information
JOURNALS FREE ACCESS

1994 Volume 17 Issue 7 Pages 973-976

Details
Abstract

A novel β-heteroglucan, called cnidirhan SIIA, was isolated from the rhizome of Cnidium officinale MAKINO. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was more than 1×107. It was composed of D-glucose, D-galactose and L-arabinose in the molar ratio of 85 : 5 : 8, in addition to small numbers of O-acetyl groups. Methylation analysis and nuclear magnetic resonance studies indicated its main structural features composed of β-1, 6-linked D-glucopyranosyl residues with both 3, 6- and 4, 6-branching points. In addition, it has both β-1, 4-linked L-arabinopyranosyl and β-1, 6-linked D-galactopyranosyl residues. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test, as well as a marked anti-complementary activity.

Information related to the author
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top