Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Effect of Vinconate on Long-Term Potentiation in a Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
Ken ARITATsutomu ARAKIKatsuro SHUTOMasamichi SATOH
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1994 Volume 17 Issue 7 Pages 987-989

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Abstract

We investigated the effect of vinconate on the long-term potentiation of population spikes following the stimulation of mossy fibers in the CA3 pyramidal layer of hippocampal slices from guinea pig brain. Vinconate (10-7 and 10-6 M) dose-dependently augmented the long-term potentiation in the mossy fiber-CA3 system. This effect was reduced by treatment with scopolamine at a concentration of 10-6 M, which showed no significant change in the long-term potentiation in a mossy fiber-CA3 system. These results suggest that vinconate may augment long-term potentiation in the mossy fiber-CA3 system partly via activation of the cholinergic system.

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© The Pharmaceutical Society of Japan
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