Antitumorigenic Activities of Chalcones. I. Inhibitory Effects of Chalcone Derivatives on 32Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA)

Susumu IWATA; Takeshi NISHINO; Nobuyuki NAGATA; Yoshiko SATOMI; Hoyoku NISHINO; Shoji SHIBATA

doi:10.1248/bpb.18.1710

Antitumorigenic Activities of Chalcones. I. Inhibitory Effects of Chalcone Derivatives on ³²Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA)

岩田進, 西野剛史, 永田信幸, 里見佳子, 西野輔翼, 柴田承二

著者情報

キーワード: 3-hydroxy-3'-methylchalcone, 3-hydroxy-4'-methylchalcone, isoliquiritigenin, antitumor promoting activity, structure-activity relationship

ジャーナルフリー

1995 年 18 巻 12 号 p. 1710-1713

DOI https://doi.org/10.1248/bpb.18.1710

詳細

抄録

More than forty chalcone derivatives were synthesized to examine their structure-activity relationship against tumorigenesis. As a primary screening test, the inhibitory activities of the chalcones for the ³²Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) were examined. 3-Hydroxy-chalcone derivatives possessing methyl group in 3'-, 4'-, or 2'-position and isoliquiritigenin homologs showed potent inhibitory activities in the phosphorylation test, which suggests their antitumorigenic effects.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）