Effects of Dicarboxylic Acids on Fatty Acid-Metabolizing Enzymes in Cultured Rat Hepatocytes

抄録

A clear chain-length dependent effect was observed for peroxisomal fatty acid β-oxidation and carnitine acetyltransferase and also for mitochondrial carnitine palmitoyltransferase in primary cultures of rat hepatocytes. The extent of modulation of peroxisomal β-oxidation was higher with even-carbon numbered dicarboxylic acids than with odd-carbon numbered ones, although such a tendency was not detected in the mitochondrial reactions. These results indicate difference in the effect of fatty acid-derived dicarboxylates on peroxisomal and mitochondrial functions.