Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibitory Effects of Cucurbitane Triterpenoids on Epstein-Barr Virus Activation and Two-Stage Carcinogenesis of Skin Tumor. II
木島 孝夫高崎 みどり小塚 睦夫長尾 常敦岡部 光入野 信人中隅 哲郎徳田 春邦西野 輔翼
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1995 年 18 巻 2 号 p. 284-287

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To search for possible anti-tumor-promoters, we carried out a primary screening of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya (Cucurbitaceae) using an in vitro synergistic assay system. Of these glucosides, cayaponosides B (5), B3 (7), D (8), D3b(22) and C2 (23) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 5 and 23 exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

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