NON-INTERCALATIVE AND SEQUENCE-SELECTIVE INTERACTION OF NITROPYRENE/ACRIDINE-SKELETON WITH NUCLEOTIDES : APPLICATION OF THE DEXTRAN-COUPLING METHOD

Mizue SHICHITA; Rumiko SHIMAZAWA; Osamu NAKAJIMA; Hidetoshi MIZOGUCHI; Yuichi HASHIMOTO; Shigeo IWASAKI

doi:10.1248/bpb.18.637

Mizue SHICHITA, Rumiko SHIMAZAWA, Osamu NAKAJIMA, Hidetoshi MIZOGUCHI, Yuichi HASHIMOTO, Shigeo IWASAKI

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Keywords: dextran, intercalator, nucleotide, ultrafiltration

JOURNAL FREE ACCESS

1995 Volume 18 Issue 4 Pages 637-639

DOI https://doi.org/10.1248/bpb.18.637

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Abstract

Water-insoluble typical intercalators, acridine and pyrene, were converted to water-soluble species, Dex-Pyr and Dex-Acr, respectively, by coupling with dextran polymer. By the use of these dextran-coupled intercalators, interactions of acridine- and pyrene-skeletones with various nucleotides in aqueous solutions were analyzed.

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