Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Bioavailability of Calcium from Calcium Carbonate, DL-Calcium Lactate, L-Calcium Lactate and Powdered Oyster Shell Calcium in Vitamin D-Deficient or -Replete Rats
Naoko TSUGAWAToshio OKANORaita HIGASHINOTamiko KIMURAYukiko OSHIOYumiko TERAOKAChie IGARASHIIkuko EZAWATadashi KOBAYASHI
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1995 Volume 18 Issue 5 Pages 677-682

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Abstract

The bioavailability of calcium from various calcium sources in humans and animals has been the subject of investigation for many years and there is considerable controversy as to the relative bioavailability of different calcium salts. Most of the studies have used a calcium balance technique which has numerous problems in terms of performance and interpretation. Using a method for evaluating the efficacy of calcium from calcium salts used for plasma calcium metabolism and bone mineralization, we examined the bioavailability of calcium from four commercially available calcium salts, namely calcium carbonate, DL-calcium lactate, L-calcium lactate and powdered oyster shell-calcium in vitamin D-deficient or -replete rats. Among the calcium salts, the differences in bioavailability were small and not statistically significant as tested by analysis of variance in both groups of rats. Thus, we conclude that calcium is utilized to the same extent from calcium carbonate, DL-calcium lactate, L-calcium lactate and powdered oyster shell-calcium in both vitamin D-deficient and -replete rats.

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© The Pharmaceutical Society of Japan
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