Accumulation of Lauric Acid in Skin as an Enhancer for the Percutaneous Absorption of Thiamine Disulfide

Abstract

The permeation and accumulation of lauric acid (12 : 0) in rat skin as an enhancer for the percutaneous absorption of thiamine disulfide (TDS), using propylene glycol as a vehicle, were determined in vitro. 12 : 0 barely permeated through skin, and accumulated in skin. The accumulated amount increased with increasing concentrations in the vehicle (1-20%). The proportion of the accumulation to total dose was highest at a dose of 5%. A positive relationship was found between the accumulated amount of TDS and 12 : 0. It was suggested that the penetration of 12 : 0 into skin contributes to the enhanced partition of TDS to skin.