Immunoselective Cell Growth Inhibition by Antibody-Adriamycin Conjugates Targeting c-erbB-2 Product on Human Cancer Cells
1995 年 18 巻 9 号 p. 1279-1282
詳細
1995 年 18 巻 9 号 p. 1279-1282
Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric cancer cell MKN-7, but not to normal human lymphocytes.
