HYPOGLYCEMIC ACTIVITY AND STRUCTURE-ACTIVITY RELATIONSHIP OF IRIDOIDAL GLYCOSIDES

Toshihiro MIURA; Yumi NISHIYAMA; Momoyo ICHIMARU; Masataka MORIYASU; Atsushi KATO

doi:10.1248/bpb.19.160

Toshihiro MIURA, Yumi NISHIYAMA, Momoyo ICHIMARU, Masataka MORIYASU, Atsushi KATO

著者情報

キーワード: iridoidal glycoside, deacetylasperulosidic acid methyl ester hypoglycemic activity, structure-activity relationship

ジャーナルフリー

1996 年 19 巻 1 号 p. 160-161

DOI https://doi.org/10.1248/bpb.19.160

詳細

抄録

Four iridoidal glycosides, deacetylasperulosidic acid methyl ester (DE), scandoside methyl ester (SC), geniposide (GE) and gardenoside (GA) isolated from Gardenia jasminoides Ellis grandiflora Makino leaves, were tested hypoglycemic activity in mice. DE lowered the blood glucose level in normal mice. However, SC, GE and GA did not affect the blood glucose level in normal mice, indicating that the absolute configuration of 6 position hydroxy based (OH) should be essential for the biological activity.

責任著者(Corresponding author)

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