Antioxidative Effect of Sesamol and Related Compounds on Lipid Peroxidation

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The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe²⁺, on the lipid peroxidation of rat liver microsomes induced by CCl₄ or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe²⁺ were demonstrated. Consequently, sesamol and related compounds, such as 3-methoxy-4-hydroxyquinone, isosafrol, isoeugenol, eugenol, 3, 4-methylenedioxyaniline, catechol. hydroxyhydroquinone, 3, 4-dimethoxyaniline and caffeic acid, echibited powerful inhibitory effects on the lipid peroxidation system investigated. In particular, isoeugenol was the most powerful inhibitor among all the sesamol-related compounds tested on the lipid peroxidation system. In addition, 1, 2-methylenedioxybenzene, ferulic acid, and 3, 4-methylenedioxynitrobenzene were also effective on the lipid peroxidation system of liposomes induced by Fe²⁺. The correlation between the structures of sesamol-related compounds and their inhibitory effect is discussed.