EFFECT OF GINSENG RADIX ON GLUT2 PROTEIN CONTENT IN MOUSE LIVER IN NORMAL AND EPINEPHRINE-INDUCED HYPERGLYCEMIC MICE

Yasuhiro OHNISHI; Sayuki TAKAGI; Toshihiro MIURA; Masaru USAMI; Mami KAKO; Eriko ISHIHARA; Hideki YANO; Keiichiro TANIGAWA; Yutaka SEINO

doi:10.1248/bpb.19.1238

Yasuhiro OHNISHI, Sayuki TAKAGI, Toshihiro MIURA, Masaru USAMI, Mami KAKO, Eriko ISHIHARA, Hideki YANO, Keiichiro TANIGAWA, Yutaka SEINO

Author information

Yasuhiro OHNISHI
Sayuki TAKAGI
Toshihiro MIURA
Masaru USAMI
Mami KAKO
Eriko ISHIHARA
Hideki YANO
Keiichiro TANIGAWA
Yutaka SEINO
Author's Organization：
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine

Keywords: Ginseng Radix, hypoglycemic activity, GLUT2, Western blotting

JOURNAL FREE ACCESS

1996 Volume 19 Issue 9 Pages 1238-1240

DOI https://doi.org/10.1248/bpb.19.1238

Details

Abstract

The oral administration of the water extract of Ginseng Radix (GR) to normal and epinephrine-induced hyperglycemic mice caused a significant decrease in the blood glucose level 4 h after its administration. The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) protein content from mouse liver significantly increased in the orally GR-treated normal and epinephrine-induced hyperglycemic mice compared to that in the controls. These results suggest that the hypoglycemic activity of GR is presumably due, at least in part, to the increment of GLUT2 protein content.

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