REMARKABLE INHIBITORY EFFECTS OF HYBRID LIPOSOMES ON THE GROWTH OF HL-60 CELLS COUPLED TO INDUCTION OF APOPTOSIS

Chikara IMAMURA; Yoshinori KEMURA; Yoko MATSUMOTO; Ryuichi UEOKA

doi:10.1248/bpb.20.1119

Biological and Pharmaceutical Bulletin

Online ISSN : 1347-5215
Print ISSN : 0918-6158

REMARKABLE INHIBITORY EFFECTS OF HYBRID LIPOSOMES ON THE GROWTH OF HL-60 CELLS COUPLED TO INDUCTION OF APOPTOSIS

Chikara IMAMURA, Yoshinori KEMURA, Yoko MATSUMOTO, Ryuichi UEOKA

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Keywords: liposome, apoptosis, in vitro antitumor activity

JOURNALS FREE ACCESS

Volume 20 (1997) Issue 10 Pages 1119-1121

DOI https://doi.org/10.1248/bpb.20.1119

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Abstract

The hybrid liposomes (90 mol% DMPC/10 mol% C₁₂(EO)₁₀ or C₁₂(EO)₁₂) have a highly inhibitory effect on the growth of tumor cells (HL-60). The induction of apoptosis by the hybrid liposomes in HL-60 cells was revealed on the basis of flow cytometry and DNA electrophoresis.

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