Psychotropic Drugs and Local Anesthetics Restore Cardiolipin-Inhibited Mammalian DNA Topoisomerase I Activity

Gulzar SHAH; Kazuhiro KATAOKA; Akiko UENO; Yoshihisa OHTSUKA; Tohru MIZUSHIMA; Kazuhisa SEKIMIZU

doi:10.1248/bpb.20.1233

Gulzar SHAH, Kazuhiro KATAOKA, Akiko UENO, Yoshihisa OHTSUKA, Tohru MIZUSHIMA, Kazuhisa SEKIMIZU

著者情報

キーワード: DNA topoisomerase I, acidic phospholipid, cardiolipin, chlorpromazine, cytotoxicity

ジャーナルフリー

1997 年 20 巻 12 号 p. 1233-1234

DOI https://doi.org/10.1248/bpb.20.1233

詳細

抄録

The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.

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