Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
CP2289, a New 5-HT3 Receptor Ligand : Agonistic Activities on Gastroenteric Motility
Yasuo SATOMegumi IMAIKazuko AMANOKatsuyoshi IWAMATSUFukio KONNOYasushi KURATAShiro SAKAKIBARAMitsugu HACHISUMasaaki IZUMINorio MATSUKIHiroshi SAITO
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1997 Volume 20 Issue 7 Pages 752-755

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Abstract

A new 5-HT3 receptor ligand, CP2289, was synthesized and pharmacologically tested. Although CP2289 inhibited the Bezold-Jarisch reflex, it contracted the excised ileal muscle of mice, rats and guinea pigs. This response may reflect a partial agonist character of CP2289 in the gut. In vivo antiemetic and gastric emptying tests gave similar results.

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© The Pharmaceutical Society of Japan
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