Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
The Effects of Crude Polysaccharide Fractions of 4 Kinds of Kampo-hozai Administered Orally on Nitric Oxide Production by Murine Peritoneal Macrophages
Kiyoshi TERAWAKIMitsuhiko NOSEYukio OGIHARA
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1997 Volume 20 Issue 7 Pages 809-811

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Abstract

In order to characterize the pharmacological role of the crude polysaccharide fraction in kampo-hozai, we chose 4 kinds of kampo-hozai, Shosaiko-to, Daisaiko-to, Hachimi-jio-gan and Hochu-ekki-to, and studied the effects of their crude polysaccharide fractions on nitric oxide (NO) production by 3% thioglycollate-induced murine peritoneal macrophage. Oral administration of these fractions for 7 d augmented lipopolysaccharide (LPS, 0.1-10 μg/ml)-induced NO production by peritoneal macrophages. These results suggest the possibility that a crude polysaccharide fraction affect the macropharge function in most kampo-hozai.

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© The Pharmaceutical Society of Japan
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