Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Formulation of Liposomes with a Soybean-Derived Sterylglucoside Mixture and Cholesterol for Liver Targeting
Kazuyuki SHIMIZUYoshie MAITANIKozo TAKAYAMATsuneji NAGAI
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1997 Volume 20 Issue 8 Pages 881-886

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Abstract

In this study, we investigated a liposomal formulation of dipalmitoylphosphatidylcholine (DPPC) with a soybean-derived sterylglucoside mixture (SG) and cholesterol (Ch) for targeting the liver in mice. We found two distribution profiles of liposomes (reverse-phase evaporation vesicles, REV) in the liver depending on the concentration of Ch and SG in vivo; Ch tends to enhance liposomes containing 10 mol% SG accumulation in the liver, but to decrease those containing 20 mol% SG, and it prolongs the circulation in blood. Dicetylphosphate did not enhance liver targeting by liposomes with SG and Ch. More DPPC/SG/Ch-liposomes (6 : 1 : 3) were significantly taken up by cultivated hepatocytes than DPPC/SG/Ch-liposomes (6 : 0 : 4), suggesting a glucose residue. The optimal composition for the maximal liver targeting was a mixture of 0.2 μm DPPC/SG/Ch-liposomes (REV) at a molar ratio of 6 : 1 : 3. This composition of liposomes was distributed 3 times greater in hepatocytes than non-parenchymal cells 1 h after intravenous injection.

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