Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Synergistic Effect of Naphtoquinones on the Mutagenicity of Nitroarene
Kiyomi OHMORIMichiko KISHITadayoshi NAKAOKANaoki MIYATA
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1999 Volume 22 Issue 1 Pages 90-92

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Abstract

Nitro reduction is a critical step in the mutagenic activation of nitroarene. Nitroarene and quinone are known to be reduced by common enzymes, and thus, naphthoquinone (NQ) was studied for its effects on the mutagenicity of nitroarene in the Ames test using Salmonella typhimurium TA98 without S9. The mutagenicity of 1, 3-dinitropyrene in TA98 was found to increase 9- and 6-fold as much in the presence of 70 nmol/plate of 2-methyl-1, 4-NQ and 2-hydroxy-1, 4-NQ, respectively. Mutagenicity also became greater in 1, 3, 5-trinitronaphthalene, 1-nitropyrene and 3-nitrofluoranthene. Seventy nmol/plate of 2-methyl-1, 4-NQ incerased the mutagenicity of 1-nitropyrene by 10.5-fold as much.

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© The Pharmaceutical Society of Japan
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