Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
Marked Reduction in the Minimum Inhibitory Concentration (MIC) of β-Lactams in Methicillin-Resistant Staphylococcus aureus Produced by Epicatechin Gallate, an Ingredient of Green Tea (Camellia sinensis)
Sumiko SHIOTAMasato SHIMIZUTohru MIZUSHIMAHideyuki ITOTsutomu HATANOTakashi YOSHIDATomofusa TSUCHIYA
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Volume 22 (1999) Issue 12 Pages 1388-1390

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Abstract

We found that epicatechin gallate, a constituent of an extract of tea leaves (green tea) markedly lowered the minimum inhibitory concentration (MIC) of oxacillin and other β-lactams, but not of other antibacterial agents tested, in strains of methicillin-resistant Staphylococcus aureus. The antibacterial action of epicatechin gallate plus oxacillin was a bactericidal one.

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© The Pharmaceutical Society of Japan
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