Structure-Activity Relationships of Lignans from Schisandra chinensis as Platelet Activating Factor Antagonists

Im Seon LEE; Keun Young JUNG; Sei Ryang OH; Si Hyung PARK; Kyung Seop AHN; Hyeong-Kyu LEE

doi:10.1248/bpb.22.265

Im Seon LEE, Keun Young JUNG, Sei Ryang OH, Si Hyung PARK, Kyung Seop AHN, Hyeong-Kyu LEE

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Keywords: Schisandra chinensis, platelet activating factor antagonist, dibenzocyclootadiene, lignan

JOURNAL FREE ACCESS

1999 Volume 22 Issue 3 Pages 265-267

DOI https://doi.org/10.1248/bpb.22.265

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Abstract

We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC₅₀, 2.1×10^-6 M) in this study.

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