Role of Prostaglandin E₂ and Leukotriene B₄ in Skin Reaction Induced by Transdermal Application of Propranolol

抄録

Dermal application of propranolol (PRL) induced formation of erythema and edema, and pseudoeosinophil infiltration in epidermis and dermis at the application site in guinea pigs. We investigated the production of prostaglandin E₂ (PCE₂) and leukotriene B₄ (LTB₄) at the application site of PRL and the role of these inflammatory chemical mediators in the occurrence of the skin reactions. PGE₂ was found to be produced at the application site slightly after the accumulation of PRL released from the adhesive bandage in the patch test, and the amount of PGE₂ increased continuously, with a peak value obtained at 24 h after application. The time-course changes resembled those of Δa^* value, the index of erythema formation determined by colorimetric measurement, and edema formation. The production of PGE₂ by dermal application of PRL was suppressed by local pretreatment with dexamethasone or indomethacin. However, no notable production of LTB₄ was observed at the application site of PRL.