2000 年 23 巻 4 号 p. 511-512
Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F380B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 μM and 16 μM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 μM.