Inhibition of Cyclooxygenase-2 Expression by Diarylheptanoids from the Bark of Alnus hirsuta var. sibirica
2000 年 23 巻 4 号 p. 517-518
詳細
2000 年 23 巻 4 号 p. 517-518
Two known diarylheptanoids, oregonin (1), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-xylopyranoside and hirsutanonol (2), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCDF10A cells.
