Stable Prostaglandin I₁ Analog SM-10906 Modulates Productions of Tumor Necrosis Factor-α, Interleukin-1 and Interleukin-6 in Mouse Macrophages

抄録

The present study investigated the effects of stable agonist for prostaglandin (PG) I₂ receptor with PGI₁ skeleton, SM-10906, on pro-inflammatory cytokine production by mouse peritoneal macrophages (PEMs) in comparison with PGE₁ and PGI₂. In mouse PEMs, SM-10906 and PGE₁ slightly enhanced interleukin (IL)-6 secretion, but had no effects on tumor necrosis factor-α (TNF-α) or IL-1 production. SM-10906 concentration-dependently inhibited TNF-α, IL-1 and IL-6 releases from lipopolysaccharide-activated mouse PEMs, as with PGE₁, PGI₂ and cAMP analog. Additionally, SM-10906, PGE₁ and PGI₂ caused concentration-dependent accumulation of cAMP contents in mouse PEMs. It is concluded that PGI₁ analog SM-10906 exerts anti-inflammatory effects on stimulated mouse PEMs by increasing in cAMP levels, as with E-series of PG.