Biomedical Research on Trace Elements
Online ISSN : 1880-1404
Print ISSN : 0916-717X
ISSN-L : 0916-717X
短報
カルノシンが鉄吸収に及ぼす影響
五十嵐 香織蛭沼 利江子竹市 博臣木村 修一榎本 秀一
著者情報
キーワード: カルノシン, , 吸収, 胃液分泌
ジャーナル フリー

2004 年 15 巻 4 号 p. 370-372

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抄録

Iron is an essential element for all living organisms. It is a key functional component of oxygen transporting and storage molecules and of many enzymes. It is well established that the bioavailability of non-heam iron from foods is enhanced by the presence of meat. Carnosine (β-alanyl-L-histidine) is found in millimolar concentrations in the skeletal muscle and brain of animals. Carnosine was reported to act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. Thus, to investigate the effects of carnosine for the absorption of iron, we determined the change of serum iron concentration in rats administered ferrous sulfate and carnosine using cannulation system. We further determined the effect of carnosine for the gastric secretion in rats. The serum iron concentration in rats administered with ferrous sulfate in the presence of carnosine was significantly higher than that in rats administered with ferrous sulfate after treatment for 15 min. Furthermore, the carnosine-administered rats exhibited a significant increase in pepsine activity and output. These results suggest that carnosine may facilitate the velocity of iron absorption by enhancing iron solubility.

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© 2004 日本微量元素学会
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