2008 年 19 巻 4 号 p. 297-307
Selenium (Se) is an essential trace element and component of glutathione peroxidase known to be involved in the reduction of free radicals. Reduction of body Se is easily induced by the external Se-deficient environment, but the symptoms of Se deficiency such as cardiomyopathy, weakness of muscle strength, muscle pain, anemia, and white nail are rarely seen in human. In this review paper, we describe that the appearance of functional disorders following Se deficiency in rats is not easily appeared, and that Se deficiency in rats reduces toxic threshold of anticancer drug “adriamycin”. And also, we consider the significance of prevention of Se deficiency based on the results of these animal studies.