Biomedical Research on Trace Elements
Online ISSN : 1880-1404
Print ISSN : 0916-717X
ISSN-L : 0916-717X
特集:セレンの多彩な機能
セレン欠乏とその予防
—動物実験からの考察—
松田 晃彦武田 隆久木村 美恵子
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ジャーナル フリー

2008 年 19 巻 4 号 p. 297-307

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Selenium (Se) is an essential trace element and component of glutathione peroxidase known to be involved in the reduction of free radicals. Reduction of body Se is easily induced by the external Se-deficient environment, but the symptoms of Se deficiency such as cardiomyopathy, weakness of muscle strength, muscle pain, anemia, and white nail are rarely seen in human. In this review paper, we describe that the appearance of functional disorders following Se deficiency in rats is not easily appeared, and that Se deficiency in rats reduces toxic threshold of anticancer drug “adriamycin”. And also, we consider the significance of prevention of Se deficiency based on the results of these animal studies.

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© 2008 一般社団法人 日本微量元素学会
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