急性肺傷害における金属粒子の関わり

抄録

The diseases that cause acute respiratory failure are acute respiratory distress syndrome (ARDS), acute pulmonary embolism, acute exacerbations of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) and asthma attacks. Especially, ARDS is a major cause of acute respiratory failure. A standard clinical protocol for ARDS treatment has not been established as yet, and ARDS mortality remains at 40–50%. Therefore, discovering new compounds to prevent ARDS development is very important. Although pathogenic mechanisms of these diseases are unknown, metal particles (zinc, nickel, titanium, etc.) or fine particulate matter (PM2.5) are reportedly involved the onset of these pulmonary diseases. In this review, we first introduce about the etiology and treatment of ARDS, and then introduce studies on metal particles and lung injuries in humans and animals. Further, we introduce our recent study about carnosine’s preventive effects on lipopolysaccharide (LPS)-induced lung injury.